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2205.07360

Qualitative dynamics of chemical reaction networks: an investigation using partial tropical equilibrations

Aurélien Desoeuvres, Peter Szmolyan, Ovidiu Radulescu

correctmedium confidence
Category
Not specified
Journal tier
Specialist/Solid
Processed
Sep 28, 2025, 12:56 AM

Audit review

The paper formalizes the partial tropical equilibration constraints (27)–(29), proves the solution set is a polyhedral complex built from finite choices of minima, and defines the associated tropically truncated system E′; it also gives the Tyson-cell-cycle reduced model obtained at total tropical equilibration. The candidate independently reconstructs the same encoding of minima into affine constraints, the branch/complex structure, and E′, and on the Tyson model derives exactly the reduced system reported in the paper. Minor differences (ε* chosen as 0.1 instead of 1/11, and using closures for strict inequalities) do not affect correctness and are consistent with the paper’s implementation and robustness remarks. Key statements and the final reduced model match the paper’s results.

Referee report (LaTeX)

\textbf{Recommendation:} minor revisions

\textbf{Journal Tier:} specialist/solid

\textbf{Justification:}

The audited claims—polyhedral-complex structure of partial tropical equilibrations, branch construction via minima choices, and the definition of the truncated system—are correct. The Tyson-model reduction derived in the paper is reproduced exactly by the model solution. Remaining points are largely expository (strict vs non-strict inequalities, hyperbolicity assumptions) and do not undermine correctness.