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2206.04217

Decomposition of Boolean networks: An approach to modularity of biological systems

Claus Kadelka, Reinhard Laubenbacher, David Murrugarra, Alan Veliz-Cuba, Matthew Wheeler

correctmedium confidence
Category
Not specified
Journal tier
Strong Field
Processed
Sep 28, 2025, 12:56 AM

Audit review

The paper proves (i) every Boolean network with a well-defined restriction (e.g., fanout-free) decomposes uniquely (up to Q-consistent reordering) into a semi-direct product of simple networks obtained from the SCCs of its wiring diagram (Theorem 4.3), and (ii) for a two-block decomposition F = F1 oP F2, the attractors satisfy D(F) = ⊔_{C1∈D(F1)} C1 ⊕ D(F2^{C1}), where F2^{C1} is a non-autonomous system driven by a periodic representative of C1 (Theorem 4.8). These are precisely the statements and constructions used in the candidate solution: it builds the product along a topological ordering of SCCs using restrictions to define the couplings, and derives the attractor decomposition via the skew-product viewpoint and periodic forcing. The solution’s arguments align closely with the paper’s definitions and proofs for restriction, semi-direct product, non-autonomous dynamics, and the disjoint union claim for D(F) (see Definition 3.13; Theorem 4.1/4.3; Definition 4.5; Theorem 4.8). Minor differences are present only in exposition (e.g., the model invokes the functoriality of restriction, which is consistent with the paper’s restriction construction but not stated verbatim). Overall, both are correct and essentially the same proof structure.

Referee report (LaTeX)

\textbf{Recommendation:} minor revisions

\textbf{Journal Tier:} strong field

\textbf{Justification:}

The manuscript presents a coherent decomposition theory—structural and dynamic—for Boolean networks with a well-defined restriction, establishing unique modular factorization and a non-autonomous attractor composition principle. The results are correct, conceptually elegant, and well-motivated by applications. Minor revisions would improve rigor and readability where proofs are terse or where properties (e.g., functoriality of restriction) are used implicitly rather than stated explicitly.