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2207.10160

Applications of PDEs and Stochastic Modeling to Protein Transport in Cell Biology

Maria-Veronica Ciocanel

correcthigh confidence
Category
Not specified
Journal tier
Specialist/Solid
Processed
Sep 28, 2025, 12:56 AM

Audit review

The paper outlines the same Lyapunov–Schmidt reduction on L(λ,ν)=A+νC+ν^2D−λI, obtains the quadratic dispersion relation λ(ν)=⟨ψ0,Cu0⟩/⟨ψ0,u0⟩·ν + ⟨ψ0,(D−CÃ^{-1}C̃)u0⟩/⟨ψ0,u0⟩·ν^2, and then inverts the Fourier transform to produce the long-time Gaussian profile u_l(y,t)=(2πσ_eff t)^{-1/2}exp(−(y+v_eff t)^2/(2σ_eff t)) with v_eff,σ_eff as above; it also gives the explicit two-state formulas v_eff=c β2/(β1+β2), σ_eff=d β1/(β1+β2)+c^2 β1β2/(β1+β2)^3. These match the candidate solution’s steps and coefficients exactly. The candidate solution provides a more detailed and rigorous sketch (projectors Π0,Q0, solving the range equation, spectral projector P(ik), small-|k| semigroup decomposition, error control O(t^{-1})), which the paper references but does not detail. Hence, both are correct, with substantially the same method and results, the model adding technical detail beyond the paper’s expository outline. Key matches appear in the paper’s equations (4)–(8) and discussion of the two-state model and Gaussian asymptotics .

Referee report (LaTeX)

\textbf{Recommendation:} minor revisions

\textbf{Journal Tier:} specialist/solid

\textbf{Justification:}

The paper correctly presents the LS-based dispersion expansion and long-time Gaussian asymptotics for linear advection–reaction–diffusion systems with state switching, with accurate effective transport coefficients and two-state formulas. The candidate solution mirrors this approach with greater technical detail. Minor clarifications on assumptions (spectral gap, normalization/prefactor, and remainder control) would improve mathematical completeness without altering results.