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2209.14751

Low-dimensional models of single neurons: A review

Ulises Chialva, Vicente González Boscá, Horacio G. Rotstein

correctmedium confidence
Category
Not specified
Journal tier
Specialist/Solid
Processed
Sep 28, 2025, 12:56 AM

Audit review

The paper’s quadratization section states that one Taylor-expands the current-balance and gating equations about the V-nullcline extremum (Ve, x1,e), retains up to second order in V and first order in x1, translates the extremum to the origin, and obtains dv/dt = σ a v^2 − w, dw/dt = ε[α v − λ − w] with explicit biophysical parameter mappings (their eqs. (29)–(39)). The candidate solution reproduces exactly these steps, including the definitions of v, w, and the expressions for a, α, ε, λ, gL, gj, β, ξ, and Fe, matching the paper’s formulas term-by-term. The only subtlety is that the mixed ΔV·Δx term in the V-equation is neglected; this is consistent with how the paper presents the final normal form, even though the text’s phrase “neglecting all terms with power bigger than two in V and bigger than one in x1” could be read as allowing the mixed term. Overall, the candidate faithfully mirrors the paper’s quadratization procedure and results, so both are correct and essentially the same derivation .

Referee report (LaTeX)

\textbf{Recommendation:} minor revisions

\textbf{Journal Tier:} specialist/solid

\textbf{Justification:}

This section provides a concise and accurate derivation-to-result pathway for quadratizing HH-type models near a V-nullcline extremum, with explicit parameter mappings that make the reduced quadratic model biophysically interpretable. It is well-aligned with established literature and will be valuable to both theorists and modelers. A couple of clarifying remarks (notably on the dropped mixed term and on assumptions at the extremum) would make the presentation watertight without altering results.