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2211.10836

Natural parameter conditions for singular perturbations of chemical and biochemical reaction networks

Justin Eilertsen, Santiago Schnell, Sebastian Walcher

correctmedium confidence
Category
Not specified
Journal tier
Strong Field
Processed
Sep 28, 2025, 12:56 AM

Audit review

The candidate solution reproduces the core statements of Proposition 1 and Proposition 2 for the s=1 case, using continuity on the compact set K* to control the ratio σ̂n/(σ1σn−1) (matching the paper’s Proposition 1) and a Viète-based exact identity plus an IFT expansion for the small eigenvalue to derive the ε-linear scaling of |λn/Σi<nλi| and the global chain bounds (matching the paper’s Proposition 2). The paper proves these via a different identity (Lemma 3) and obtains an O(ε) remainder term, but the hypotheses (Blanket Assumptions and Lemma 2 spectral gap) and conclusions align. A minor notational issue in the paper where ε* appears on both sides of a chain is noted by the model; reading the left bound with ε_* is consistent with Definition 2. Overall the paper’s arguments and the model’s derivation are both correct, with different but compatible proof routes .

Referee report (LaTeX)

\textbf{Recommendation:} minor revisions

\textbf{Journal Tier:} strong field

\textbf{Justification:}

The audited results are correct and the framework is valuable for deriving computable small parameters in biochemical singular perturbations. The proofs are sound; minor notation clarifications would enhance readability. The work bridges theory and practice and is a meaningful step toward quantitative error control in reductions.