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2402.03529

Basic principles drive self-organization of brain-like connectivity structure

Carlos Calvo Tapia, Valeri A. Makarov, Cees van Leeuwen

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Category
Not specified
Journal tier
Specialist/Solid
Processed
Sep 28, 2025, 12:56 AM

Audit review

The paper defines the three rewiring principles precisely (P1 by distance, P2 by external field, P3 by heat-kernel diffusion with H(τ) = −e^{−τL}) and implements a probabilistic algorithm S0–S2; it then demonstrates via simulations that combining the principles produces modular small-world networks and that peaks of small-worldness occur along lines q + p ≈ 0.23 (for the tested τ), i.e., r ≈ 0.77, with lateral and radial fields alike. These are presented empirically, not as theorems, and the authors themselves note the dependence on τ, not universality. Consequently, a general mathematical guarantee (e.g., that the dynamics must reach S > 1 for broad classes of initial graphs and parameters, or that maximizers always satisfy p + q = c(τ)) is not proved in the paper and, per our audit, remained open at the stated cutoff. The candidate solution offers plausible heuristics and partial arguments (e.g., small-τ expansion for P3 and coupling to small-world models) but no complete proof; it also correctly cautions that the constant 0.23 is model/parameter-dependent rather than universal. Therefore, the mathematically general claims are likely open as of the cutoff, while the paper’s empirical findings are consistent with its stated scope.

Referee report (LaTeX)

\textbf{Recommendation:} minor revisions

\textbf{Journal Tier:} specialist/solid

\textbf{Justification:}

The manuscript clearly formulates three biologically motivated rewiring principles, implements them in a transparent algorithm, and demonstrates robust emergence of modular small-world structure and higher-order superstructures under lateral and radial fields. The methodology is sound for empirical exploration, and connections to prior adaptive rewiring work are appropriate. However, strong general statements should be tempered; the dependence on τ and other parameters deserves more systematic quantification, and the relative contributions of P1, P2, and P3 to clustering and efficiency could be more explicitly dissected.