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2408.01528

Can multivariate Granger causality detect directed connectivity of a multistable and dynamic biological decision network model?

Abdoreza Asadpour, KongFatt Wong-Lin

incompletelow confidence
Category
Not specified
Journal tier
Specialist/Solid
Processed
Sep 28, 2025, 12:56 AM

Audit review

The paper empirically demonstrates, using MVGC/PWGC with sliding 100 ms windows, that (i) in the 420–520 ms stimulus-locked window INH↔U and forward INH→{L‑SM,R‑SM}, U→{L‑SM,R‑SM} are detected with stronger drive to L‑SM on correct and to R‑SM on error trials, and (ii) in the first 100 ms post-response, INH↔U, L‑M↔R‑M, INH/U→{L‑M,R‑M}, U→L‑SM, L‑SM→L‑M, and R‑SM→U are found, with correctness-contingent edges R‑SM→{L‑SM,R‑M} (correct) and INH→L‑SM (error); unifying these recovers most, but not all, of the original architecture and yields some spurious links . However, the paper stops short of a formal proof and explicitly notes missing connections and spurious ones, as well as using BY-FDR (not BH) for multiplicity control . The candidate solution correctly reproduces the specific edge lists and offers a plausible local-linear (Jacobian/TV‑VAR) rationale, but it overclaims 100% recovery of a target set and assumes BH-FDR and certain activation/lag conditions that the paper does not establish empirically; the paper itself reports only “most” recovery with some misses/spurious edges despite large samples . Hence both are incomplete: the paper is empirically sound but not a proof, and the model’s proof-style claims hinge on assumptions not verified in the paper and conflict with its stated limitations.

Referee report (LaTeX)

\textbf{Recommendation:} major revisions

\textbf{Journal Tier:} specialist/solid

\textbf{Justification:}

The paper convincingly demonstrates, via simulation, that MVGC/PWGC can reveal dynamic directed interactions in a multistable decision network under appropriate windowing, and it responsibly reports spurious/missing connections and methodological limits. However, clarifications (e.g., window overlap vs. step, precise multiple-testing procedure) and a more granular accounting of which edges are recovered/missed would strengthen the contribution. The candidate’s theoretical rationale is helpful but overreaches by claiming 100\% recovery under assumptions that are not verified in the empirical setup.