Exploring the Multifractal Behavior of the Human Genome T2T-CHM13v2.0: Graphical Representations and Cytogenetics

The paper’s core claims are plausible and internally consistent with standard CGR/multifractal practice and with the qualitative findings it reports (e.g., chr9 and chrY showing the widest spectra; MC(12) ≈ 2% error; BGR better at high-q, MC better at low-q; MC cannot reproduce fixed stripe-like patterns) . However, the paper does not fully specify key quantitative procedures (e.g., the discrete estimator for τ(q) from the two resolutions 4^10 and 4^12, or the exact formula for the “average percentage error” used to claim 2%) despite defining the continuum relations (Eqs. 5–7) and drawing aggregate conclusions . The candidate model solution precisely fills many methodological gaps (two-scale τ estimator, treatment of q<0 zeros, explicit E(model) definition, FCGR/k-mer equivalence), but it does not execute the computations or report numbers. Net: the paper is under-specified for reproducibility, and the model is a rigorous protocol without results—both are incomplete.