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2504.06715

Bistability and complex bifurcation diagrams generated by waning and boosting of immunity

Francesca Scarabel, Mónika Polner, Daniel Wylde, Maria Vittoria Barbarossa, Gergely Röst

correctmedium confidence
Category
Not specified
Journal tier
Strong Field
Processed
Sep 28, 2025, 12:56 AM

Audit review

The paper derives the characteristic equation W(λ,τ)=P(λ,τ)+Q(λ,τ)e^{-λτ}, defines F(ω,τ)=|P(iω,τ)|^2−|Q(iω,τ)|^2=ω^2(ω^4+a1(τ)ω^2+a0(τ)), and proves that the delay interval admitting positive roots is finite (Proposition 1) and that the endemic equilibrium eventually becomes stable for any ν (Lemma 2). These constructions, including explicit μ(τ), σ(τ), a0(τ), a1(τ), match the candidate’s setup and limits a0∞>0, a1∞ (the paper gives equivalent closed forms) and the ensuing boundedness of the Hopf window J± (see the model statement (1), the definition of μ,σ,P,Q and F, and the asymptotic formulas in (8) ). The paper also notes stability at τ=0 as theoretically expected . The candidate’s proof employs a clean sum-of-squares identity at μ=0 to control F for large τ and a direct Jacobian argument for τ≈0, then infers finiteness of switches from bounded τ and ω together with the phase condition; this differs in technique from the paper’s Beretta–Kuang monotonic-switch framework but reaches the same conclusions (finite τ-window for Hopf, stability for small and large τ, finitely many switches). Minor caveat: the candidate’s argument that only finitely many zeros occur inside a bounded τ-window relies on isolated zeros and bounded k but does not explicitly supply the monotonicity used in the paper to count switches; still, the conclusions align with the paper’s results and setup (J± bounded; finite switch count) .

Referee report (LaTeX)

\textbf{Recommendation:} minor revisions

\textbf{Journal Tier:} strong field

\textbf{Justification:}

The analytical framework is correct and well-aligned with established methods for delay-dependent coefficients, and the numerical results are comprehensive and illuminating. Minor additions (explicit small-delay stability lemma; concise SIR-limit derivation) would improve accessibility without altering the core results.