Back to search
2506.01606

The Boundary Reproduction Number for Determining Boundary Steady State Stability in Chemical Reaction Systems

Matthew D. Johnston, Florin Avram

correctmedium confidence
Category
Not specified
Journal tier
Strong Field
Processed
Sep 28, 2025, 12:56 AM

Audit review

The candidate solution reproduces the paper’s Theorem 1 proof structure: (i) use the siphon property f(0, y)=0 to obtain a block lower–triangular Jacobian at an X-free boundary equilibrium and deduce that stability depends on the diagonal blocks, (ii) define the boundary reproduction number R_x* = ρ(FV^{-1}) under F ≥ 0 and V a Z-matrix with V^{-1} ≥ 0, and (iii) prove the M-matrix/next-generation threshold equivalence that s(F−V) < 0 iff ρ(FV^{-1}) < 1 and s(F−V) > 0 iff ρ(FV^{-1}) > 1, then (iv) handle the conservation-law case by reducing to the stoichiometric class and showing the reduced Jacobian equals F−V. These steps match the theorem statement and Appendix A proof, as well as the setup in Section 3.1 and Definition 6 of the paper .

Referee report (LaTeX)

\textbf{Recommendation:} minor revisions

\textbf{Journal Tier:} strong field

\textbf{Justification:}

The article correctly adapts the next-generation matrix framework to chemical reaction networks and proves a clear, useful threshold criterion for local stability/instability at boundary equilibria. The main theorem is sound and accompanied by helpful heuristics and examples. Clarifications concerning the role of critical siphons and a brief discussion of the equality case R=1 would improve completeness and reader understanding.