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2506.05992

Cancer model with moving extinction threshold reproduces real cancer data

Frank Bastian, Hassan Alkhayuon, Kieran Mulchrone, Micheal O’Riordain, Sebastian Wieczorek

wrongmedium confidence
Category
math.DS
Journal tier
Specialist/Solid
Processed
Sep 28, 2025, 12:56 AM

Audit review

The paper’s condition for the existence of two positive equilibria in Model 2 (its fold threshold for s) is derived by solving f(x)=0 and f′(x)=0 and then eliminating x, but the printed result s = (1/(μν))(νr/(ν+1))^{ν+1} has the wrong μ dependence and an extra 1/ν. The correct threshold is s* = [(νr)/(ν+1)]^{ν+1} μ^{−ν}, obtained by evaluating the concave maximum of g(x)=νrx−νμx^{(ν+1)/ν}. The candidate solution derives the correct g_max and all subsequent conclusions (number and stability of equilibria) follow correctly. The discrete-time moving-threshold derivation and its large-ν/log-linear approximation match the paper’s formulas exactly.

Referee report (LaTeX)

\textbf{Recommendation:} major revisions

\textbf{Journal Tier:} specialist/solid

\textbf{Justification:}

Substantive modeling contribution with clear biological interpretation and useful phase-wise approximations, but the printed analytical fold threshold for s is incorrect. Because this condition underlies the existence of two positive equilibria (A and K), it must be corrected. With this fix and minor clarifications on approximation validity, the work is publishable.